溃疡性结肠炎患者血清白细胞介素-lβ和白细胞介素-13水平变化

Expression and clinical significance of inflammatory factors IL - l beta and IL -13 in ulcerative colitis

目的探讨溃疡性结肠炎患者炎性因子白细胞介素-lβ(IL-lβ)和白细胞介素-13(IL-13)水平变化及临床意义.方法选取聊城市第四人民医院2016年1-12月收治的溃疡性结肠炎患者120例作为观察组,选择同期120例健康体检者作为对照组.采用ELLSA方法检测两组血清IL-lβ和IL-13水平.结果观察组的血清IL-lβ水平为(192.3±23.6)ng/L,明显高于对照组血清IL-lβ水平(169.8±20.3)ng/L(t=8.234,P=0.025);观察组的血清IL-13水平为(869.5±56.8)ng/L,明显低于对照组血清IL-13水平(893.2±52.1)ng/L(t=5.957,P=0.036).观察组中重度患者血清IL-lβ水平为(159.8±21.6)ng/L,均高于轻度、中度患者,差异有统计学意义(F=16.931,P=0.018);观察组中重度患者血清IL-13水平为(1132.5±142.3)ng/L,均低于轻度、中度患者,差异有统计学意义(F=15.049,P=0.022).Pearson相关分析显示,观察组血清IL-lβ和IL-13水平呈负相关(r=-0.547,P=0.036).结论血清IL-lβ和IL-13水平且其在不同严重程度的消化性溃疡中也具有不同程度的表达,可作为消化性溃疡患者的检测指标,为临床诊断消化性溃疡提供依据.

Objective To investigate the expression and clinical significance of inflammatory factors IL - l beta and IL - 13 in ulcerative colitis. Methods From January 2016 to December 2016,120 patients with ulcerative colitis in the Fourth People's Hospital of Liaocheng were selected as observation group. During the same period, 120 healthy volunteers were selected as control group. The serum levels of IL - l and IL - 13 were detected by ELLSA method in the two groups. Results The serum IL - l level in the observation group was (192. 3 ± 23. 6)ng/ L,which was significantly higher than (169. 8 ± 20. 3)ng/ L in the control group (t = 8. 234,P = 0. 025). The serum level of IL- 13 in the observation group was (869. 5 ± 56. 8)ng/ L,which was significantly lower than (893. 2 ± 52. 1)ng/ L in the control group (t = 5. 957,P = 0. 036). In the observation group,the serum IL - l level in the severe patients was (159. 8 ± 21. 6)ng/ L,which was significantly higher than that in the mild and moderate patients (F = 16. 931,P =0. 018). In the observation group,the serum IL -13 level in the severe patients was (1132. 5 ±142. 3)ng/ L,which was significantly lower than that in the mild and moderate patients (F = 15. 049,P = 0. 022). Pearson correlation analysis showed that the level of serum IL - l beta and IL - 13 in the observation group was negatively correlated ( r =- 0. 547,P = 0. 036). Conclusion The serum IL - l beta and IL - 13 levels in peptic ulcer patients with different severity has different degrees of expression,which can be used as the detection index of patients with peptic ulcer,and can provide the basis for clinical diagnosis of peptic ulcer.