同期放化疗在非手术食管癌治疗中的应用

Application of concurrent chemoradiotherapy in the treatment of non - operative esophageal cancer

食管癌是上消化道常见的恶性程度较高的肿瘤之一,在中国,食管癌的发病率和死亡率均占全球一半以上.中国及亚洲其他地区以鳞状细胞癌为主,欧美其他国家则以腺癌为主,因此在其生物学特性、发病机制以及相关治疗方式的选择存在较大差异性.随着放疗技术、机器设备、化疗药物与靶点药物不断更新进步同时也为食管癌的非手术治疗带来了更多的选择余地.目前手术仍然是食管癌患者的首选方式,但对于局部晚期或远处转移的不可手术的患者以及可手术而不愿手术的患者来说,放射治疗的同时行化学治疗被认为是标准的非侵入治疗手段.

Esophageal cancer is one of the most common malignant tumors of upper digestive tract. Squamous cell carcinoma dominates in China and other parts of Asia,while adenocarcinoma dominates in Europe and the United States. Therefore,there are great differences in the pathogenesis of its biological characteristics and the selection of relevant treatment methods. Currently,surgery is still the preferred method for patients with esophageal cancer. But for patients locally advanced or distant metastases who are inoperable and for patients who are operable but do not want surgery,concurrent chemotherapy with radiotherapy is considered the standard noninvasive treatment.