蛋氨酸调控动物主要生理功能的机制

Methionine regulates the major physiological functions of animals

蛋氨酸是动物机体的必需氨基酸,同时也是饲粮中的限制性氨基酸.蛋氨酸可作为底物参与蛋白质的合成,同时也可作为甲基供体参与DNA, RNA和蛋白质等的甲基化,或通过转巯基途径发挥抗氧化功能以及参与多胺的形成.这些代谢途径对动物的生产性能、抗氧化能力、免疫功能以及肠道健康等方面有着重要的调控作用.本文对近年来关于蛋氨酸调控生理功能的机制进行综述,以期为蛋氨酸代谢机制的研究及科学应用提供参考.

Methionine is an essential amino acid in animals and it is also a limited amino acid in the diet. Methionine can be used as a substrate to participate in protein synthesis. It can also be used as a methyl donor involved in the methylation of DNA, RNA and protein, or through the transfer of sulfhydryl pathways to play anti-oxidative roles and participate in the formation of polyamines. These metabolic pathways have important regulatory effects on animal performance, antioxidant capacity, immune function, and intestinal health. This article reviews the mechanism of methionine modulating physiological functions in recent years in order to provide reference for the study and scientific application of methionine metabolism mechanism.