基于监测、流行病学和结果数据库的胸腺神经内分泌肿瘤患者临床特征及预后分析

Clinical characteristics and prognosis of patients with neuroendocrine tumors of the thymus: a study based on the Surveillance, Epidemiology, and End Results database

目的探讨胸腺神经内分泌肿瘤(NETT)的临床特征及潜在的预后因素。方法选取美国国立癌症研究所监测、流行病学和结果(SEER)数据库2007年1月至2014年12月收录经病理确诊的NETT患者的临床资料进行回顾性研究。Cox比例风险模型分析影响预后的相关因素。结果139例NETT患者的中位诊断年龄为59岁,年龄(58±17)岁。男性95例,女性44例,男女比例为2.2∶1。中位总生存时间为90个月。单因素分析显示,肿瘤分期(P=0.001)、肿瘤分级(P=0.001)、是否手术(P=0.003)与患者预后相关。多因素分析表明,肿瘤分级是影响患者预后的独立因素(HR:5.70;95%CI1.75~18.58;P=0.004)。结论NETT是一种罕见的侵袭性强的恶性肿瘤,肿瘤分级是影响患者预后的独立危险因素,高分化者预后好于低分化者。

Objective To investigate the clinical manifestations and potential prognostic factors of neuroendocrine tumors of the thymus (NETT). Methods The clinical data of 139 patients with pathologically confirmed NETT from the Surveillance, Epidemiology, and End Results (SEER) database in National Cancer Institute between January 2007 and December 2014 were retrospectively analyzed. Cox proportional hazard regression was used to assess the prognostic influencing factors of NETT. Results The median age at diagnosis of 139 patients with NETT was 59 years old, and age was (58±17) years old. There were 95 males and 44 females, and the ratio was 2.2∶1. The median overall survival time was 90 months. Univariate analysis showed that the tumor stage (P = 0.001), the tumor grade (P = 0.001) and the surgery (P = 0.003) were associated with prognosis. Multivariate analysis showed that the tumor grade was the independent prognostic factor for the patients with NETT (HR: 5.70;95% CI 1.75-18.58;P = 0.004). Conclusion NETT is a rare malignancy with tremendous aggressiveness. Tumor grade is an independent risk factor for the prognosis of the patients with NETT, and the prognosis of well-differentiated patients is better than that of poorly differentiated patients.