腹泻患儿大便培养及轮状病毒检测结果与血清锌、肌酸激酶同工酶水平的关系

The Relationship of the Results of Faeces Culture and of Rotavirus Detection with the Level of Serum Zinc and of Creatine Kinase Isoenzyme in Child-Patient with Diarrhea

为探讨腹泻患儿大便培养及轮状病毒检测结果与血清锌、肌酸激酶同工酶(CK-MB)水平的关系,选取2016年1月至2018年1月于我院住院接受治疗的380例腹泻患儿作为研究对象,根据大便培养及轮状病毒检测结果将其分为单纯菌群失调组(A组,184例)、轮状病毒感染组(B组,135例)和非轮状病毒感染组(C组,61例),同时选择50例普通外伤门诊患儿作为健康对照组(D组)。比较上述4组患儿血清锌、CK-MB水平及异常率。结果显示,1)血清锌及CK-MB水平:相比D组,A、B、C 3组患儿血清锌水平显著降低(P <0.05),血清CK-MB水平显著升高(P <0.05)。相比A组,B组和C组患儿血清锌水平显著降低(P <0.05)、CK-MB显著升高(P <0.05)。B组和C组患儿血清锌、CK-MB水平比较差异无统计学意义(P>0.05)。2)血清锌、CK-MB异常率:相比D组,A、B、C 3组患儿血清锌异常率显著升高(P <0.05),A组患儿血清CK-MB异常率无明显变化(P>0.05),B组、C组患儿血清CK-MB异常率显著升高(P <0.05)。B组与C组血清锌、CK-MB异常率明显高于A组,P <0.05;而B组与C组血清锌、CK-MB异常率比较差异无统计学意义(P>0.05)。结果表明,血清锌与CK-MB检测有助于鉴别菌群失调性腹泻与感染性腹泻,同时腹泻患儿血清锌常降低,而感染性腹泻患儿血清CK-MB常升高,临床应重视腹泻患儿补锌及感染性腹泻相关心肌损伤的防治。

This study was to explore the relationship of the results of faeces culture and of rotavirus detection with the level of serum Zinc(SZ)and of creatine kinase isoenzyme(CK-MB),enrolled 380cases of diarrhea treated in author's hospital(2016-01-2018-01)and divided them into group A,B,C according to the results of faeces culture and of rotavirus detection,i.e group A(184cases)as simple dysbacteriosis group, group B(135cases)as rotavirus infection group,group C(61cases)as non-rotavirus infection group,at the same time selected 50outpatients'child-patients with common injury as control group (group D);then compared SZ and CK-MB level between above four groups.As results,1)in SZ level,group A,B and C were significantly decreased than group D,but in CK-MB level increased(all,P <0.05);meanwhile,compared with group A SZ level of group B,C was significantly decreased(P <0.05),but CK-MB level increased (all,P <0.05);in above two indexes there was no statistical difference between group B and group C(P >0.05).2)compared with group D,group A,B and C the abnormal ratio of SZ was significantly increased( P <0.05),as for the abnormal ratio of CK-MB group A had no changes(P >0.05),but in group B and C increased significantly(P <0.05);Also,in the abnormal ratio of SZ and of CK-MB group B and group C were all significantly increased than group A(P <0.05),but there was no statistical difference between group B and group C(P >0.05).Results show that detecting SZ and CK-MB level are helpful to differetiate diarrhea being dysbacteriosis or being infectious one;at the same time it should be clinically attenting supplement of Zinc-regent due to diarrhea child-patient's SZ decreased,and preventing &curing infectious diarrhea patient's relevant myocardial injury due to their CK-MB often increased.