副溶血性弧菌分泌系统在致病力中作用的研究进展

Role of Vibrio parahaemolyticus secretion system in pathogenicity

致病菌借助分泌系统将特异蛋白直接注入宿主细胞内,破坏宿主细胞内的多种信号通路,是导致细菌定殖和感染的有效途径。作为一种重要的食源性致病菌,副溶血性弧菌(Vibrio parahaemolyticus)的Ⅲ型分泌系统(Type Ⅲ secretion system,T3SS)和Ⅵ型分泌系统(Type Ⅵ secretion system,T6SS)是其对宿主细胞产生致病性的重要因素。本文综述了副溶血性弧菌T3SS和T6SS效应物在致病力中的具体作用,以及相关调控机理,为进一步了解由副溶血性弧菌导致的病症,研究其致病机理以及寻找致病性靶标提供参考。

Specialized substrates are injected into a host cell through secretion system, to destroy various signal pathways, which is an effective way for bacterial colonization and infection. Vibrio parahaemolyticus being an important foodborne pathogen, its Type Ⅲ Secretion System(T3SS) and Type VI Secretion System(T6SS) are important virulence factors to the hosts. In this review, we summarize the specific roles of T3SS and T6SS effectors in pathogenicity and the related regulatory mechanisms. This paper provides a reference to further understand the diseases caused by Vibrio parahaemolyticus, to investigate its pathogenesis and find the pathogenic targets.