雄激素受体在三阴性乳腺癌中的表达及预后意义

Expression of androgen receptor in triple-negative breast cancer and its prognostic significance

目的探讨雄激素受体(androgen receptor,AR)在三阴性乳腺癌中的表达情况及其与临床病理特征的关系。方法三阴性乳腺癌病人133例,临床及病理资料完整、无远处转移、未行新辅助化疗。应用免疫组化法检测肿瘤组织中AR的表达情况,分析AR表达与临床病理特征及预后的相关性。结果 133例病人中AR表达阳性38例,阳性率为28.6%。AR阳性与年龄(≥50岁)、绝经状态、较低的Ki-67指数和CK5/6阴性相关(P<0.05),与初潮年龄、体质量指数、是否合并糖尿病、是否有恶性肿瘤家族史、组织学分级、淋巴结状态、脉管癌栓、临床分期、EGFR状态等因素无相关性(P>0.05)。生存分析显示,AR阳性组病人在总生存上优于AR阴性组,无病生存无差异。结论 AR阳性与部分临床病理特征有一定的相关性,且AR阳性的三阴性乳腺癌病人有更好的总生存,提示AR或许可以成为三阴性乳腺癌新的预后指标或治疗靶点。

Objective To investigate the expression of androgen receptor(AR)in triple-negative breast cancer and its prognostic significance.Methods We collected the clinical data of 133 female patients with triple-negative breast cancer.The expression of AR in breast cancer tissues was detected by immunohistochemical staining.We analyzed the relationship of AR expression with the other clinicopathological characteristics and survival.Results The positive rate of AR expression was 28.6%(38/133).AR expression were significantly related to elder age(≥50 years old),menopause,lower Ki-67 index and negative CK5/6(P<0.05).There was no significant relationship between AR expression and menarche age,BMI,diabetes,family history of malignant tumor,histological grade,lymph node status,vascular invasion,TNM stage and EGFR(P>0.05).Kaplan-Meier curves identified that AR expression was positively correlated with overall survival(P<0.05).No significant relationship was found in disease-free survival.Conclusion AR expression were significantly related to some of the clinicopathological characteristics and overall survival,which indicates that it may be a new prognosis factor and therapeutic target.