丹参酮注射液联合胺碘酮对急性心肌梗死并发房颤病人血清癌胚抗原125水平的影响

Effect of Tanshinone Injection and Amiodarone on Serum Carcinoembryonic Antigen 125 in Patients with Acute Myocardial Infarction Complicated with Atrial Fibrillation

目的探讨丹参酮注射液联合胺碘酮对急性心肌梗死并发房颤病人血清癌胚抗原125(CA-125)水平的影响。方法选取我院收治的急性心肌梗死并发房颤病人148例,按随机数字表法分为两组。对照组74例予以胺碘酮治疗,研究组74例在对照组基础上予以丹参酮ⅡA磺酸钠注射液治疗。比较两组血清CA-125、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、血清N末端脑钠肽前体(NT-proBNP)、同型半胱氨酸(Hcy)、髓过氧化物酶(MPO)水平,观察两组临床疗效、不良反应发生率及缺血事件发生率等。结果治疗14 d后对照组总有效率(82.43%)低于研究组(93.24%),具有统计学意义(P<0.05);与对照组比较,研究组治疗后血清CA-125、CRP、TNF-α水平较低,治疗后血清NT-proBNP、Hcy、MPO水平较低,具有统计学意义(P<0.05);研究组不良反应发生率(5.40%)低于对照组(17.57%),具有统计学意义(P<0.05);研究组心力衰竭、房颤复发、心源性死亡的发生率低于对照组,具有统计学意义(P<0.05)。结论丹参酮注射液联合胺碘酮能有效降低急性心肌梗死并发房颤病人血清CA-125及相关细胞因子水平,临床疗效优于胺碘酮治疗,且不良反应发生率低,可有效改善病人预后。

Objective To investigate the effect of tanshinone injection and amiodarone on serum carcinoembryonic antigen 125(CA-125) levels in patients with acute myocardial infarction(AMI) complicated with atrial fibrillation(AF). Methods One hundred and forty-eight patients with AMI complicated with AF were randomly divided into two groups:control group( n =74) treated with amiodarone,and treatment group( n =74) treated with tanshinone injection and amiodarone.The levels of serum CA-125,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) N-terminal pro-brain natriuretic peptide (NT-proBNP),homocysteine(Hcy) and myeloperoxidase(MPO) were observed.The incidences of clinical efficacy,adverse reactions,and ischemic events were compared between the two groups. Results The total clinical effective rate was significantly higher in treatment group than that in control group(93.24% vs 82.43%, P <0.05).The levels of serum CA-125,CRP,TNF-α,NT-proBNP,Hcy,MPO in treatment group after treatment were lower than that in control group( P < 0.05).The incidence of adverse reactions were lower in treatment group than that in control group(4.23% vs 16.90%, P <0.05).The incidences of heart failure,AF recurrence,and cardiogenic death in treatment group was lower than that in control group( P <0.05). Conclusion Tanshinone injection and amiodarone can effectively reduce the serum CA-125 and related cytokines levels,improve the treatment effect,reduce the incidence of adverse reactions,and effectively improve the prognosis in patients with AMI complicated with AF.