心搏骤停后脑复苏药物研究进展

Progress in pharmaceutical research for cerebral resuscitation after cardiac arrest

随着心肺复苏(CPR)技术的普及,自主循环恢复(ROSC)成功率逐渐提高,心搏骤停患者的存活率及神经功能结局有所改善。目前心搏骤停后脑复苏治疗手段有限,除亚低温应用于临床外,绝大多数药物尚停留在动物实验阶段。寻找有效的脑保护药物成为脑复苏研究领域的热点。针对心搏骤停后脑复苏药物研究进展进行回顾,以期能更好地、更有针对性地研究这些药物的脑保护作用机制。

With the popularization of cardiopulmonary resuscitation (CPR) technology, the success rate of restoration of spontaneous circulation (ROSC) is gradually improved, and the survival rate and neurological outcome of patients with cardiac arrest are improved. Currently, therapeutic methods for cerebral resuscitation after cardiac arrest are limited. In addition to mild hypothermia for clinical application, the majority of drugs remain in the animal experimental stage. Finding effective brain protection drugs has become a hot spot in the field of brain resuscitation research. This article will review the pharmaceutical progress of research for cerebral resuscitation after cardiac arrest, so that we can study the brain protection mechanism of these drugs better and more targeted.