瑞舒伐他汀对脑梗死患者颈动脉斑块的影响

Effect of Rosuvastatin on Carotid Plaque in Patients with Cerebral Infarction

目的观察瑞舒伐他汀钙片对脑梗死患者颈动脉斑块的临床疗效。方法选取自2016年1月至2017年1月于辽阳县中心医院神经内科收治脑梗患者60例,采用前后对照的研究方法,所有患者均在控制血糖、营养脑细胞、维持体内水液电解质平衡、检测生命体征等对症治疗的基础上口服瑞舒伐他汀钙片,10 mg,日1次口服,连续口服6个月,观察患者口服瑞舒伐他汀前后颈动脉斑块变化情况。结果斑块数量治疗前为:(2.97±0.87)个,治疗后为:(2.33±0.91)个,两组数据比较差异没有统计学意义(P> 0.05)。斑块厚度:治疗前为(1.97±0.51)mm,治疗后为(1.34±0.51)mm,两组数据比较差异具有统计学意义(P <0.05)。说明经过口服瑞舒伐他汀钙片治疗6个月后粥样硬化斑块的厚度有所减少,较治疗前有统计学差异。结论瑞舒伐他汀钙片可以较少脑梗患者颈动斑块厚度,安全有效,值得推广。

Objective To observe the clinical efficacy of Rosuvastatin Calcium Tablets on carotid plaque in patients with cerebral infarction.Methods From January 2016 to January 2017 in Liaoyang county hospital admitted patients with cerebral infarction in 60 cases,by using contrast method,all the patients were given in the control of blood glucose,brain cells nutrition,maintaining the water electrolyte balance,detection of vital signs and other symptomatic treatment based on Rosuvastatin Calcium Tablets,10 mg,QD continuous oral administration for 6 months,observe the changes of patients with oral rosuvastatin atorvastatin statins before and after carotid artery plaque.Results The number of plaques before treatment was (2.97±0.87),and after treatment:(2.33±0.91),the difference between the two groups was not statistically significant (P >0.05).Plaque thickness:(1.97±0.51) mm before treatment and (1.34±0.51) mm after treatment.The difference between the two groups was statistically significant (P <0.05).It indicated that the thickness of atherosclerotic plaque decreased after 6 months of oral rosuvastatin calcium tablets,which was statistically different from before treatment.Conclusion The number of Rosuvastatin Calcium Tablets and carotid atherosclerosis in patients with cerebral infarction decreased less plaque thickness,safe and effective,worthy of promotion.