参芪平喘颗粒提取工艺研究

Study of Extraction Processes in Shenqipingchuan Granules

目的优选参芪平喘颗粒最佳提取工艺。方法以毛蕊异黄酮葡萄糖苷含量为考察指标,通过单因素试验确定煎煮次数、加水量、煎煮时间的3个因素水平;以毛蕊异黄酮葡萄糖苷含量和固形物得率的综合评分值为指标,按照上述单因素试验优选的因素水平进行正交试验,筛选出参芪平喘颗粒的最佳提取工艺。结果最佳提取工艺为处方药材加10倍量水提取2次,每次1.5 h。结论该提取工艺稳定可行,并能较好的保证制剂质量。

OBJECTIVE To optimize the extraction technology of Shenqipingchuan Granules. METHODS With the contents of calycosin-7-glucoside as index,single factor tests were used to choose separately three levels of examine times of extraction,amount of water,extraction time.With the comprehensive scores of the contents of calycosin-7-glucoside and dry extract as index,L9( 3~4) orthogonal design was used to adopted examine times of extraction,amount of water,extraction time. RESULTS The optimical extraction technology conditions were as follows.All herbs were boiled with ten-folds amount water of herbs and extracted for two times,1 h each time. CONCLUSION This extraction process is stable and practical,and can well guarantee the quality of preparation.