白细胞介素17A及其信号通路与急性呼吸窘迫综合征的研究进展

Advancement of interleukin-17A and its signaling pathway in acute respiratory distress syndrome

白细胞介素17A(IL-17A)是Th17细胞产生的特异性促炎性细胞因子,通过诱导产生多种细胞因子参与机体的免疫调节和炎症反应过程,在呼吸、免疫、血液等多个系统疾病及肿瘤的发生发展中发挥重要作用。IL-17A及其信号通路在急性呼吸窘迫综合征发生发展过程中的作用机制是目前研究的热点,有利于为此类疾病的诊断、病情评估及预后评价。本文就IL-17A及其信号通路与急性呼吸窘迫综合征相关的研究进展进行综述。

Interleukin (IL)-17A is a characteristic pro-inflammatory cytokine, secreted by helper T cell (Th cell)17, induces diverse cytokines to participate in the process of immunoregulation and inflammatory response, so it plays an important role in the occurrence and development of multiple systemic diseases and tumors, such as respiratory, immune and hematological system.The potential values of IL-17A and its signal pathway in acute respiratory distress syndrome (ARDS) are the hotspot of current research, which is beneficial in the diagnosis, condition and prognosis assessment.This review focuses on the IL-17A and its signal pathways in ARDS.