高原地区阻塞性睡眠呼吸暂停低通气综合征患者研究进展

Obstructive sleep apnea-hypopnea syndrome at high altitude

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是睡眠医学中的常见疾病,其发病率呈逐年上升趋势。此疾病主要通过慢性间歇性低氧和睡眠片段化对人体产生损害,导致呼吸、循环、代谢等多系统损害。而高原地区低氧的特殊环境,会造成频繁的中枢性呼吸暂停,其与阻塞性呼吸暂停并存,患者病情更加复杂。因此对于高原地区OSAHS患者的研究是有必要的。本文对目前的研究在流行病学特点、病理机制、器官功能、睡眠监测特点和治疗等方面作一综述。

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common disease in sleep medicine.The incidence of OSAHS has been increasing year by year.This disease mainly causes damage to the human body through chronic intermittent hypoxia and sleep fragmentation, resulting in multiple system damage such as breathing, circulation, and metabolism.The special environment of hypoxia at high altitude causes frequent central apnea, which coexists with obstructive apnea, and the patient′s condition is more complicated.Therefore, it is necessary to study the patients with OSAHS at high altitude.This article reviews the current research on epidemiological characteristics, pathological mechanisms, organ function, sleep monitoring characteristics and treatment.