生命早期呼吸道感染与儿童哮喘的关系

Relationship between early life respiratory infections and childhood asthma

生命早期的病毒感染,尤其是呼吸道合胞病毒和人鼻病毒与儿童哮喘关系密切。人鼻病毒下呼吸道感染的首次喘息可作为哮喘倾向的标志物,而生命早期的呼吸道合胞病毒毛细支气管炎(特别是严重发作者)可能对哮喘发作有致病作用。病毒感染与气道细菌微生物环境相互作用是儿童哮喘的重要决定因素。

Viral infections in early life, especially respiratory syncytial virus and human rhinovirus, are closely related to childhood asthma.An initial wheezing of the lower respiratory tract infection of human rhinovirus can serve as a marker of asthma predisposition, whereas respiratory syncytial virus bronchiolitis (particularly severe infection) in early life can have a causative role in asthma attacks.The interaction of viral infections with the bacterial microbiological environment of respiratory tract is an important determinant of childhood asthma.