清热凉血方联合西药治疗儿童过敏性紫癜风热伤络型42例临床观察

Clinical observation on 42 cases of Henoch-Schonlein purpura with impairment of collaterals due to wind-heat type in children treated by Qingre Liangxue Fang (清热凉血方)combined with Western medicine

目的观察清热凉血方联合西药治疗儿童过敏性紫癜风热伤络型的临床疗效。方法选取我院2015年1月至2017年2月收治的过敏性紫癜风热伤络型患儿84例,采用随机数字表法分为对照组和治疗组,各42例。对照组采用常规西药治疗,治疗组在对照组治疗方法的基础上联合中药清热凉血方治疗。治疗1月并随访2周后,比较2组的临床疗效、治疗前后免疫球蛋白水平变化及不良反应发生情况。结果对照组总有效率为71.4%,治疗组为95.2%,2组比较,差异有统计学意义(P<0.01)。2组治疗前IgA、IgG、IgM水平比较,差异无统计学意义(P>0.05),具有可比性。2组治疗后IgM水平无明显变化,与同组治疗前比较,差异无统计学意义(P>0.05);IgA、IgG水平下降显著,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更明显(P<0.05)。2组总不良反应发生率经统计学分析,差异无统计学意义(P>0.05)。结论清热凉血方联合西药治疗儿童过敏性紫癜风热伤络型临床疗效显著,可明显改善患儿的免疫功能,且安全性高,值得临床推广应用。

Objective To observe the clinical efficacy of Qingre Liangxue Fang(清热凉血方) combined with Western medicine in the treatment of children of Henoch-Schonlein purpura with impairment of collaterals due to wind-heat type.Methods Eighty-four cases of Henoch-Schonlein purpura with impairment of collaterals due to wind-heat type admitted to our hospital from January 2015 to February 2017 were divided into control group and treatment group according to random number table,with 42 cases in each.The control group was treated with routine Western medicine,and the treatment group was combined with Qingre Liangxue Fang on the basis of the treatment of the control group.After treatment for 1 month and follow-up for 2 weeks,the clinical efficacy,the changes of immunoglobulin levels before and after treatment and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the control group was 71.4%,that of the treatment group was 95.2%,there was statistically significant difference between the two groups(P<0.01).Before treatment,the levels of IgA,IgG and IgM in both groups showed no significant difference(P>0.05),and they were comparable.After treatment,there was no significant change in IgM level in the two groups,and there was no statistically significant difference compared with the same group before treatment(P>0.05);the levels of IgA and IgG decreased significantly,the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the decrease in the treatment group was more significant(P<0.05).The total incidence of adverse reactions between the two groups showed no significant difference by statistics analysis(P>0.05).Conclusion Qingre Liangxue Fang combined with Western medicine in the treatment of Henoch-Schonlein purpura with impairment of collaterals due to wind-heat type in children has significant clinical efficacy,which can significantly improve immunological function of children patients with high security.It deserves clinical promotion and application.