乌鲁木齐市男男性行为者HPV HBV感染状况及影响因素

HPV and HBV infection status and influencing factors among men who have sex with men in Urumqi

目的了解乌鲁木齐市(简称乌市)男男性行为者(MSM)人乳头瘤病毒(HPV)和乙型肝炎(简称乙肝)病毒(HBV)感染的现状及影响因素。方法 2017年9月至2018年3月,采用滚雪球的方法招募MSM,填写在线问卷收集人口学特征、高危行为特征及HBV感染史等相关信息,并采集肛周棉拭子和血样通过实验室检测确定HPV和HBV感染情况,采用多因素Logistic回归模型分析HPV和HBV感染的影响因素。结果共招募373名MSM,肛周HPV的感染率为48.8%(182名),乙肝病毒表面抗原(HBsAg)阳性率为5.9%(22名),HPV/HBV双重感染率为3.5%(13名)。多因素Logistic回归分析显示,被插入性行为为主是肛周HPV感染的主要危险因素[校正比值比(aOR)=1.84,95%可信区间(CI):1.21～2.81];未接受包皮环切和既往有肝病史是HBV感染的危险因素(aOR=8.80,95%CI:1.92～40.30;aOR=57.94,95%CI:14.25～235.59)。结论乌市MSM的HPV感染率较高,HBV感染率低于一般人群;提倡MSM肛交性行为中使用安全套预防HPV感染;进行包皮环切术及肝病史者尽早接种乙肝疫苗预防HBV感染。

Objective To assess prevalence and influencing factors of HPV and HBV infection among men who had sex with men(MSM) in Urumqi. Methods A total of 373 MSM were recruited by using the "snowballing" sampling method from Sept 2017 to Mar 2018 in Urumqi. Online questionnaires were administrated to collect information on demographic characteristics and high-risk behavior characteristics, hepatitis B infection history, and other infection-related factors. Laboratory tests were also conducted to determine HPV and HBV infection. Multivariate logistic regression model was used to identify the influencing factors. Results The overall HPV infection rate was 48.8%(182/373), the positive rate of HBsAg was 5.9%(22/373), and the infection rate of HPV/HBV was 3.5%(13/373). Multiple logistic regression analysis showed that the risk factor for HPV infection was anal sex(aOR=1.84, 95%CI: 1.21-2.81), and the risk factors for HBV infection were uncircumcised(aOR=8.80, 95%CI: 1.92-40.30) and liver disease history(aOR=57.94, 95%CI: 14.25-235.59). Conclusion The prevalence of HPV is high among MSM and HBV infection rate is lower than that among general people in Urumqi. We should publicize condom use among MSM for those who have anal intercourse, to prevention HPV infection. Circumcision and hepatitis B vaccination for those with liver disease can prevention HBV infection.