血必净注射液灌注治疗膝关节骨性关节炎的疗效观察

Therapeutic effect of intra-articular perfusion of Xuebijing injection on knee osteoarthritis

目的观察血必净注射液关节腔内灌注治疗膝关节骨性关节炎的疗效。方法选取海南省中医院骨科门诊2012年6月至2018年1月就诊的60例符合膝关节方面疾病的骨性关节炎(Ⅰ～Ⅱ)患者,按照就诊时间前后登记编号,根据编号的奇偶平均分为观察组和对照组,每组30例。观察组以血必净注射液进行膝关节腔内灌注治疗,单膝1次/5～6 d,4次为1个疗程;对照组选择玻璃酸钠注射治疗,每周1次,4次为1个疗程,共治疗3个疗程。随访6个月,分别比较治疗后1个月、3个月及6个月的有效率。结果 60例患者均成功完成6个月的随访。3个疗程治疗后,观察组患者的治疗总有效率96.7%,明显高于对照组的80.0%,差异有统计学意义(P<0.05);治疗3个月后随访,观察组患者的治疗总有效率为100.0%,略高于对照组的90.0%,但差异无统计学意义(P>0.05);治疗6个月后随访,观察组患者的治疗总有效率100.0%,也略高于对照组的93.3%,但差异无统计学意义(P>0.05)。结论血必净注射液关节腔内灌注治疗膝关节骨性关节炎疗效肯定,尤其近期疗效优于玻璃酸钠。

Objective To survey the curative effect of intra-articular perfusion of Xuebijing injection on knee osteoarthritis. Methods A total of 60 osteoarthritis(Ⅰ-Ⅱ) patients who met the knee disease were selected, who admitted to the Department of Orthopedics at Hainan Provincial Traditional Chinese Medicine Hospital from June 2012 to January 2018. After registering the number according to the visit time, they were divided into observation group and control group according to the number of parity, with 30 cases in each group. The observation group was treated with Xuebijing injection by intra-articular infusion of knee joints, once per knee for 5-6 days and four times for a course of treatment;and the control group received sodium hyaluronate injection, once a week and four times for a course of treatment. Both treatments lasted for a total of 3 courses. The followed-up duration were 6 months. The effective rates at 1 month, 3 months and 6 months after treatment were compared. Results All patients successfully completed 6 months of followed-up. After 3 courses of treatment, the total effective rate of treatment in the observation group was 96.7%, which was significantly higher than 80.0% in the control group(P<0.05). After 3 months of treatment, the total effective rate of the observation group was 100.0%, slightly higher than 90.0% of the control group(P>0.05). After 6 months of treatment, the total effective rate of the observation group was 100.0%, which was also slightly higher than 93.3% of the control group(P>0.05). Conclusion The curative effect of intra-articular perfusion of Xuebijing injection for the treatment of knee osteoarthritis is positive, especially its short-term efficacy is better than that of sodium hyaluronate.