主动脉夹层发病机制的研究进展

Advances in the pathogenesis of aortic dissection

主动脉夹层是病情凶险、进展速度快、病死率高的疾病,目前缺乏有效的干预措施。主动脉夹层与动脉粥样硬化和心血管危险因素有关,包括男性、年龄、吸烟、高血压和血脂异常等。大量证据表明糖尿病与主动脉夹层/主动脉瘤之间存在负相关。更好地了解糖尿病和主动脉夹层/主动脉瘤之间负相关的机制,可以帮助开发新的诊断和治疗方法来处理这种疾病。本文总结目前关于高血压、糖尿病和主动脉夹层发展之间关系,并对主动脉夹层发病机制及糖尿病与其负相关的细胞和分子通路,以及它们对临床转归影响做一综述。

Aortic dissection is a dangerous disease with rapid progress and high mortality. There is a lack of effective interventions. Aortic dissection is associated with atherosclerosis and cardiovascular risk factors, including male,age, smoking, hypertension, and dyslipidemia. There is substantial evidence of a negative association between diabetes mellitus and aortic dissection/aortic aneurysm. A better understanding of the mechanisms underlying the negative association between diabetes and aortic dissection/aortic aneurysm may help to develop new diagnostic and therapeutic approaches to manage the disease. This article summarizes the current knowledge on the relationship between hypertension, diabetes mellitus and aortic dissection, and reviews the pathogenesis of aortic dissection, the cellular and molecular pathways negatively related to diabetes mellitus, and their effects on clinical outcomes.