假基因在肺癌研究中的进展

Progress of pseudogenes in lung cancer research

假基因是与编码基因序列高度同源的非编码基因。研究发现,假基因具有广泛的生物学功能,参与体内细胞分化、炎症和凋亡等重要生命活动过程。在一些肿瘤疾病中,假基因可通过调控相关基因,在转录组学水平上影响肿瘤的发生、发展及侵袭转移。文章通过综述假基因在肺癌的发展机制,探讨假基因与肺癌关系的研究进展。

A pseudogene is a non-coding gene with high sequence similarity to a coding gene. Recent studies have demonstrated that pseudogenes possess multiple biologic functions and participate in important life processes such as cell differentiation, inflammation and apoptosis in vivo. In some tumor diseases, pseudogenes can affect the occurrence, development and invasion of tumors at the transcriptomic levels through regulating related genes. This paper reviews the recent research progresses of pseudogenes in the lung cancer to investigate the relationship between pseudogenes and lung cancer.