PGLA线体微创埋线后对正常人体足三里穴刺激效应的时效性观察

Observation on time-effect for the stimulating at Zusanli(ST 36) with minimally invasive embedding with PGLA in the healthy person

目的:探讨PGLA线体对正常人体经穴局部产生刺激效应的客观性及时效性,为临床使用PGLA线体行微创埋线的合理间隔周期提供依据。方法:应用医学影像学磁共振成像(MRI)扫描技术采集8例正常人体左侧足三里穴埋线前、埋线后8 h,埋线后第3、7、10、14天多个时间点埋线局部T2WI压脂及T2-Mapping 8回波序列图像,所得T2-Mapping 8回波序列图像利用相关软件生成T2-Mapping图并测量局部T2值,观察分析左侧足三里穴施行PGLA线体微创埋线后局部T2WI压脂像信号强度及T2值随时间变化的特点。结果:①埋线前左侧足三里穴局部T2WI压脂像上未见异常信号,埋线后各时间点局部T2WI压脂像上均见到高信号,其中埋线后8 h、第3天、第7天局部信号强度无较大差别,埋线后第10天局部信号强度较前减弱,埋线后第14天局部信号强度明显减弱。②与埋线前比较,埋线后各时间点T2值均显著升高(均P<0.01);埋线后1周内各时间点之间比较:埋线后8 h、埋线后第3天、埋线后第7天T2值比较差异无统计学意义(均P>0.05);埋线7d(1周)后各时间点之间比较:埋线后第10天T2值与埋线后第7天相比差异无统计学意义(P>0.05),埋线后第14天(2周)T2值与埋线后第7天(1周)相比显著下降(P<0.01)。结论:PGLA线体埋入后对正常人体经穴局部存在刺激效应,且刺激效应具有一定时效性,其有效刺激时间约为2周,临床使用同规格型号的PGLA线体施行微创埋线时其合理的间隔周期建议为2周。

Objective To explore the objectivity and time-effect of stimulating effect at acupoint with PGLA in the healthy person, and to provide a basis for the rational interval of minimally invasive embedding of PGLA. Methods Before embedding, 8 h, 3rd, 7th, 10th, 14th day after embedding, medical imaging magnetic resonance imaging(MRI)scanning technique was used to collect local T2WI pressure-lowering and T2-Mapping 8 echoes sequence image of left Zusanli(ST 36) in 8 cases of healthy person. The T2-Mapping 8 echoes sequence image was generated by the relevant software to the T2-Mapping image and the local T2 value was measured. The characteristics of local T2WI pressure-fat image signal intensity and the change of T2 value at left Zusanli(ST 36) with minimally invasive embedding with PGLA were observed and analyzed. Results ①There was no abnormal signal on the T2WI pressure-fat image on the left Zusanli(ST 36) point before the embedding. The high-signal was seen on the local T2WI pressure-fat image at each time point after embedding, there was no significant difference in local signal intensity between 8 h, 3rd and 7th day after embedding. The local signal intensity decreased on the 10 th day after embedding, and the local signal intensity decreased significantly on the 14th day after embedding.②The T2 value at each time point after embedding increased significantly compared with that before embedding(all P<0.01);there was no significant difference in T2 value among the 8 h, 3rd and 7th day after embedding(all P>0.05);there was no significant difference between the T2 value on the 7th and the10th day after embedding(P>0.05),the T2 value on the 14th day after embedding was significantly lower than that on the 7th day after embedding(P<0.01). Conclusion It has a stimulating effect on the local acupoints with minimally invasive embedding with PGLA in the healthy person, and the stimulating effect has certain time-effect. The effective stimulation time is about 2 weeks. The rational interval period for the minimally invasive embedding with the PGLA of the same specification type should be about 2 weeks.