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细胞因子诱导的杀伤细胞联合化疗对Ⅱ期胃癌术后的治疗效果及安全性 被引量：4

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摘要 目的回顾分析细胞因子诱导的杀伤(CIK)细胞联合化疗在Ⅱ期胃癌术后的治疗作用和安全性。方法接受CIK细胞联合化疗的Ⅱ期胃癌术后患者61例为联合治疗组,以同时期仅行术后化疗的Ⅱ期胃癌患者60例为对照组。观察两组外周血T淋巴细胞亚群、Karnofsky评分、无病生存期、总生存期的差别,同时观察CIK细胞治疗的不良反应。结果治疗后联合治疗组较对照组外周血CD3^+、CD4^+淋巴细胞数量显著增多(P<0.05)、CD4^+/CD8^+比值显著升高(P<0.05),其5年生存率较对照组显著提高(P<0.05),无病生存期及总生存期较对照组明显延长(P<0.05)。结论 CIK细胞联合化疗能够降低Ⅱ期胃癌术后的复发风险且安全性较好。
作者 张振 李芳芳 姚传山 王同甫 梁冰 杨清乐 马磊
机构地区 南阳市第一人民医院肿瘤内二科
出处 《中国老年学杂志》 CAS 北大核心 2019年第7期1584-1586,共3页 Chinese Journal of Gerontology
基金 河南省创新型科技人才队伍建设工程基金资助项目(No.2014GG032)
关键词 CIK细胞治疗 Ⅱ期胃癌 化疗
分类号 R735.2 [医药卫生—肿瘤]
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  • 2李慧,任秀宝,张澎,安秀梅,刘虹,郝希山.树突状细胞对CIK细胞中CD_4^+CD_(25)^+T细胞数量及免疫调节作用的影响[J].中华医学杂志,2005,85(44):3134-3138. 被引量：14
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中国老年学杂志
2019年 第7期

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