腰围与长时血压变异性的关系

The correlation between waist circumference and long-term blood pressure variability

目的探讨腰围与长时血压变异性(LBPV)的关系。方法选择参加2006、2008、2010、2012、2014年度5次健康体检的开滦研究队列人群作为观察对象,最终纳入32 444人进行统计分析。按2006年度的腰围数据将患者分为正常腰围组[<85(男性)、<80 cm(女性)]和腹型肥胖组[≥85(男性)、≥80 cm(女性)]。采用收缩压平均真实变异性(ARV)来反映LBPV。分析腰围对LBPV的影响。结果观察对象的平均年龄为(46.6±11.3)岁,男性24 493人(75.5%)。正常腰围组和腹型肥胖组的收缩压ARV分别为(12.0±6.1)、(13.0±6.8) mm Hg(P<0.05)。校正其他混杂因素后,多元线性回归分析结果显示腰围每升高1.0 cm,收缩压ARV升高0.017 mm Hg,而在男女性分组中,收缩压ARV分别升高0.013和0.023 mm Hg。多因素Logistic回归分析结果显示,校正其他混杂因素后,与正常腰围组相比,腹型肥胖组是收缩压ARV增高的危险因素(OR=1.06,95%CI 1.01～1.11)。结论随着腰围升高,LBPV增大,腰围是LBPV增高的危险因素。

Objective To explore the correlation between waist circumference(WC) and long-term blood pressure variability(LBPV). Methods A total of 32 444 subjects who participated in all the five annual physical examinations of 2006, 2008, 2010, 2012 and 2014 were chosen from the Kailuan Study Cohort for the statistic analysis. The subjects were divided into normal WC group(WC<85 cm for male,<80 cm for female) and central obesity group(WC≥85 cm for male,≥80 cm for female) according to WC in 2006. Average real variability(ARV) of systolic blood pressure(SBP) was calculated to reflect LBPV. The impact of WC on LBPV was analyzed. Results The average age was(46.6±11.3) years. Among the subjects, 24 493(75.5%) were male. The ARV of SBP in normal WC and central obesity group were(12.0±6.1) and(13.0±6.8) mm Hg, respectively. The result of multivariate linear regression showed that ARV rose 0.017 mm Hg(0.013 and 0.023 mm Hg in male and female, respectively) with per unit growth of WC after adjusting confounding factors. Multivariate Logistic analysis showed that central obesity was a risk factor for LBPV after adjusting confounding factors(OR=1.06, 95% CI 1.01-1.11). Conclusion There is a positive correlation between WC and LBPV, the higher WC, the higher LBPV. WC is a risk factor of LBPV.