小肠细菌过度生长相关疾病研究进展

Research advances in small intestinal bacterial overgrowth and its associated diseases

小肠细菌过度生长(small intestinal bacterial overgrowth,SIBO)被定义为小肠内细菌数量异常升高和(或)菌群种类改变引起的小肠内细菌过度生长,其病因较为复杂,解剖异常、小肠动力障碍、胃酸分泌不足、保护性抗菌机制异常等都有可能会导致SIBO。研究表明,SIBO在功能性胃肠病、炎症性肠病、肝硬化、慢性胰腺炎、代谢综合征、系统性硬化症等疾病中均呈现较高的阳性率,这说明小肠内细菌对诸多疾病有一定的调控作用。本文就SIBO及其相关疾病的研究进展作一综述。

Small intestinal bacterial overgrowth(SIBO) is defined as bacterial overgrowth in small intestine caused by abnormal increase in the number of intestinal bacteria and(or) changes in bacterial species. The etiology of SIBO is complex. Anatomical abnormalities, small intestinal motility disorders, inadequate gastric acid secretion and abnormal protective antibacterial mechanisms may lead to SIBO. SIBO has a high positive rate in functional gastrointestinal disorders, inflammatory bowel diseases, liver cirrhosis, chronic pancreatitis, metabolism syndrome, systemic cirrhosis and other diseases, which indicates that intestinal bacteria play a certain regulatory role in many diseases. This review aims to summarize the research progress of SIBO and its associated diseases.