摘要
It has been many years since "the tumor necrosis factor-a-converting enzyme”,also known as ADAM17/TACE, was described as "the enzyme that does it all” because of its role in neurodegenerative diseases and in several physiological processes including proteolysis, adhesion, intracellular signaling, migration and proliferation. ADAM17/TACE is an integral membrane protein that belongs to the disintegrin and metalloprotease (ADAM) family. Several years ago, Romero-Grimaldi et al.
基金
supported by the Spanish Consejería de Innovación,Ciencia y Empleo,Junta de Andalucía(P10CTS6639)
Ministerio de Econmía y Competitividad(BFU 2015-6852-R,MINECO/FEDER)(both to CC)
