^(131)I治疗儿童及青少年分化型甲状腺癌疗效的影响因素

Influencing factor on ^(131)I treatment for differentiated thyroid carcinoma in children and adolescents

目的探讨影响^(131)I治疗儿童及青少年分化型甲状腺癌(differentiated thyroid carcinoma,DTC)疗效的主要因素。方法回顾性分析接受^(131)I治疗的儿童及青少年(≤21岁)分化型甲状腺癌患者60例,分为有效组和无效组。对各种可能的影响因素进行χ~2检验或Fisher确切概率法、秩和检验,然后对有统计学意义的单因素进行logistic回归分析。结果 60例患者有效率85%(51/60)。单因素分析筛选出患者的年龄、病灶大小、病灶数目、侵犯周围组织、远处转移以及治疗前Tg、RAIU均有统计学意义(P<0.05)。多因素分析仅远处转移及治疗前Tg、RAIU与有效率显著相关。结论 ^(131)I治疗儿童及青少年分化型甲状腺癌疗效确切。治疗前Tg、RAIU、远处转移是影响效果的重要因素。

Objective To investigate the influencing factors of the curative efficacy of 131I on differentiated thyroid carcinoma(DTC)in children and adolescents.Methods A retrospective analysis of 60 children and adolescents(<21 years old)with DTC treated with 131I in our department was conducted.They were divided into effective group and ineffective group.Influential parameters were analyzed using rank-sum test,Chi-square test,Fisher exact test and logistic regression analysis.Results The success rate of initial 131I therapy was 85%.Univariate analysis factors show that age,lesion size,number of lesions,peripheral invasion,distant metastasis and pre-treatment Tg and radioactive iodine uptake(RAIU)were significant influence factors on 131I treatment(P<0.05).After logistic regression analysis,distant metastasis,pre-treatment Tg and RAIU were significantly correlated with the effective rate.Conclusion 131I therapy is effective in children and adolescents DTC patients.The distant metastasis,pre-treatment Tg and RAIU are the important influencing factors for 131I therapy.