布地奈德、复方异丙托溴铵联合氧气雾化治疗喘息性肺炎患儿的效果

Effect of Budesonide, Compound Ipratropium Bromide combined with oxygen atomization in the treatment of children with asthmatic pneumonia

目的探讨布地奈德(BUD)、复方异丙托溴铵(CIB)联合氧气(O_2)雾化治疗喘息性肺炎患儿的效果。方法选取揭阳市人民医院儿科2016年1月～2018年6月收治的195例喘息性肺炎患儿作为研究对象,随机分为实验组(99例)与对照组(96例)。实验组采用BUD+CIB联合O_2雾化治疗,而对照组仅给予BUD雾化吸入治疗,比较两组的治疗效果、肺功能变化及喘息、湿啰音、咳嗽消失时间。结果实验组的总有效率高于对照组,差异有统计学意义(P<0.05)。实验组的肺部哮鸣音、湿啰音及咳嗽的消失时间均短于对照组,差异有统计学意义(P<0.05)。两组治疗前的血氧饱和度(SaO_2)、第1秒用力呼气容积(FEV_1)、第1秒率百分比(FEV_1/FVC%)、心率(P)和呼吸频率(R)比较,差异均无统计学意义(P>0.05)。两组治疗后的SaO_2、FEV_1、FEV_1/FVC%、P和R水平均较治疗前好转,且实验组的好转程度大于对照组,差异有统计学意义(P<0.05)。结论 BUN、CIB联合O_2雾化治疗小儿喘息性肺炎效果显著,可迅速改善患儿的症状和肺功能,值得临床应用。

Objective To investigate the effect of Budesonide(BUD),Compound Ipratropium Bromide(CIB)and Oxygen(O2)atomization in the treatment of children with asthmatic pneumonia.Methods A total of 195 cases of asthmatic pneumonia admitted from January 2016 to June 2018 in the Department of Pediatrics of Jieyang People′s Hospital were selected as the research object.All patients were randomly divided into the experimental group(99 cases)and the control group(96 cases).The experimental group was treated with BUD+CIB combined with O2 atomization,while the control group was only given BUD aerosol inhalation treatment.The treatment effect,lung function changes and wheezing,wet snoring,and cough disappearance time were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).The disappearance time of the wheezing sound,wet voice and cough in the experimental group was shorter than that of the control group,and there were statistical differences(P<0.05).There was no significant difference in the level of blood oxygen saturation(SaO2),forced expiratory volume in the first second(FEV1),percentage of first second rate(FEV1/FVC%),heart rate(P),and respiratory rate(R)between the two groups before treatment(P>0.05).The level of SaO2,FEV1,FEV1/FVC%,P and R after treatment in the two groups were better than those before treatment,and the improvement of the experimental group was greater than that of the control group,the difference was statistically significant(P<0.05).Conclusion BUN,CIB combined with O2 atomization are effective in the treatment of children with asthmatic pneumonia,which can rapidly improve the symptoms and lung function of children,and it is worthy of clinical applications.