评价持续腰大池引流配合万古霉素鞘内注射对高血压脑出血患者术后颅内感染的临床疗效

To Evaluate the Clinical Effect of Continuous Lumbar Cistern Drainage Combined with Intrathecal Vancomycin Injection on Intracranial Infection in Patients with Hypertensive Intracerebral Hemorrhage after Operation

目的:探究持续腰大池引流配合万古霉素鞘内注射对高血压脑出血患者术后颅内感染的临床疗效。方法:选取2015年12月-2018年12月收治的高血压脑出血患者60例,随机分为对照组30例,观察组30例。对照组单独采用鞘内注射万古霉素治疗,观察组应用持续腰大池引流配合万古霉素鞘内注射治疗,比较两组的临床疗效。结果:在临床疗效方面,观察组治疗总有效率为93.33%,显著高于对照组的76.67%,差异有统计学意义(P<0.05)。观察组患者治疗后的颅内压明显低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的脑脊液中蛋白质及白细胞计数降低程度优于对照组,葡萄糖升高程度优于对照组,差异均有统计学意义(P<0.05)。结论:持续腰大池引流配合万古霉素鞘内注射对高血压脑出血患者术后颅内感染的临床疗效显著,值得在临床中推广应用。

Objective: To explore the clinical effect of continuous lumbar cistern drainage combined with intrathecal Vancomycin injection on intracranial infection in patients with hypertensive intracerebral hemorrhage after operation.Method:A total of 60 patients with hypertensive intracerebral hemorrhage admitted from December 2015 to December 2018 were randomly divided into control group(30 cases) and observation group(30 cases).The control group was treated with intrathecal injection of Vancomycin,while the observation group was treated with continuous lumbar cistern drainage and intrathecal injection of Vancomycin.The clinical efficacy of the two groups was compared.Result:In terms of clinical efficacy,the total effective rate of the observation group was 93.33%,significantly higher than that of the control group(76.67%),and the difference was statistically significant(P<0.05).The intracranial pressure in the observation group was significantly lower than that in the control group after treatment,the difference was statistically significant(P<0.05).After treatment,the decrease of protein and white blood cell in cerebrospinal fluid of the observation group was better than that of the control group,and the increase of glucose was better than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Continuous lumbar cistern drainage combined with intrathecal Vancomycin injection has a significant clinical effect on intracranial infection in patients with hypertensive intracerebral hemorrhage after operation,which is worthy of clinical application.