夫西地酸乳膏联合丹参酮胶囊治疗痤疮临床观察

Clinical observation on fusidic acid cream combined with tanshinone capsule in treatment of acne

目的探讨夫西地酸乳膏联合丹参酮胶囊治疗痤疮的临床疗效。方法选取北京市延庆区医院2014年6月～2015年6月诊治的痤疮患者162例,采用随机数字表法分为两组,对照组患者81例采用罗红霉素分散片联合夫西地酸乳膏治疗,观察组患者81例采用丹参酮胶囊联合夫西地酸乳膏治疗,于治疗前后行痤疮GAGS评分,记录两组患者的治疗情况(起效时间、复发时间),比较两组患者的临床疗效(治愈、显效、好转、无效、总有效)、药物不良反应情况(口唇干燥、轻度脱屑、胃部不适、皮疹反应)。结果两组患者治疗后痤疮GAGS评分较治疗前降低。观察组患者治疗后痤疮GAGS评分[(8.7±1.0)分]低于对照组[(13.4±1.5)分]。观察组患者起效时间[(4.3±1.2)d]早于对照组[(5.6±1.8)d]。观察组患者复发时间[(31.2±1.4)d]晚于对照组[(24.6±2.7)d]。观察组患者总有效率(98.8%)高于对照组(88.9%)。观察组患者药物不良反应发生率(3.7%)低于对照组(14.8%),差异均有统计学意义(P <0.05)。结论夫西地酸乳膏联合丹参酮胶囊治疗痤疮的疗效显著,且安全性高,值得临床推广使用。

Objective To explore the clinical curative effect of fusidic acid cream combined with tanshinone capsule in treatment of acne. Methods 162 patients with acne who were diagnosed and treated in Beijing Yanqing District Hospital from June 2014 to June 2015 were selected.According to the random number table method,they were divided into two groups.81 patients in the control group were treated with roxithromycin dispersible tablet combined with fusidic acid cream.81 patients in the observation group were treated with tanshinone capsule combined with fusidic acid cream.Acne GAGS scores were performed before and after treatment.Treatment situation (onset time,recurrence time) were recorded in two groups.Clinical curative effect (cure,obvious effect,improvement,ineffective,total effectiveness) and adverse drug reactions (xerocheilia,mild desquamation,stomach discomfort,rash reactions) were compared between two groups. Results Acne GAGS score after treatment were decreased compared with that before treatment in two groups.Acne GAGS score after treatment in observation group [(8.7±1.0)points] was lower than that of the control group [(13.4±1.5)points].Onset time in the observation group was [(4.3±1.2)d],earlier than that of the control group [(5.6±1.8) d].Recurrence time in the observation group was [(31.2±1.4)d],later than that in the control group [(24.6± 2.7)d].Total effective rate in the observation group (98.8%) was higher than that in the control group (88.9%).The incidence of adverse drug reactions in observation group (3.7%) was lower than that of the control group (14.8%).Differences were statistically significant (P < 0.05). Conclusion Fusidic acid cream combined with tanshinone capsule in treatment of acne has significant curative effects and it has high safety,which is worthy of clinical promotion and application.