贞芪扶正胶囊佐治对气阴不足型尖锐湿疣疗效及患者细胞免疫功能影响

Effect ofZhenqi Fuzheng capsule on patients with condyloma acuminatum of Qi and Yin deficiency syndrome and the cellular immune function of patients

目的研究贞芪扶正胶囊佐治对气阴不足型尖锐湿疣疗效及患者细胞免疫功能影响。方法研究对象选取2015年10月至2017年8月湖南中医药大学第一附属医院诊治的90例气阴不足型尖锐湿疣患者作为研究对象。采用随机数字法将其分为对照组(45例)和观察组(45例)。对照组患者给予α-干扰素、5-氟尿嘧啶软膏及足叶草脂酊剂治疗,在此基础上,观察组患者给予贞芪扶正胶囊治疗。比较两组患者的治愈率和复发率,同时比较两组患者治疗前后的瘙痒程度、病损严重程度、病损范围等症状体征积分和T淋巴细胞亚群水平。结果观察组的治愈率(77.78%)明显高于对照组(51.11%)),差异具有统计学意义(P<0.05),复发率(4.44%)明显低于对照组(20.00%),差异具有统计学意义(P<0.05);治疗后,观察组的瘙痒程度、病损严重程度、病损范围等积分均明显低于对照组,差异具有统计学意义(P<0.01),CD3^+、CD4^+及CD4^+/CD8^+值均明显高于对照组,差异具有统计学意义(P<0.01),CD8^+明显低于对照组,差异具有统计学意义(P<0.01)。结论贞芪扶正胶囊佐治对气阴不足型尖锐湿疣疗效显著,能明显改善患者症状体征,促进细胞免疫功能恢复,且安全性较高,值得在临床推广。

Objective To study the effect of Zhenqi Fuzheng capsule in the treatment of patients with condyloma acuminatum(CA) of Qi and Yin deficiency syndrome and the cellular immune function of patients. Methods 90 patients with CA of Qi and Yin deficiency syndrome in our hospital from October 2015 to August 2017 were selected and randomly divided into control group and observation group, 45 cases in each group. The control group were treated with α-interferon, 5-fluorouracil ointment and podophyllin tincture for treatment, on which basis, the observation group was treated with Zhenqi Fuzheng capsule. The cure rate and recurrence rate were compared between the two groups, and the degree of pruritus, severity of lesion, extent of lesion and the level of T lymphocyte subsets were compared between before and after treatment in the two groups. Results The cure rate of the observation group(77.78%) was significantly higher than that of the control group(51.11%), with statistically significant difference(P<0.05). The recurrence rate of the observation group(4.44%) was significantly lower than that of the control group(20.00%), with statistically significant difference(P<0.05). After treatment, the degree of pruritus, the severity of lesion, loss of range points in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.01). The content of CD3^+, CD4^+ and CD4^+/CD8^+ in the observation group was significantly higher than that of the control group(P<0.01), while the content of CD8^+ was significantly lower than that of the control group, all with statistically significant differences(P<0.01). Conclusions Zhenqi Fuzheng capsule is of remarkable effect and safety in the treatment of patients with CA of Qi and Yin deficiency syndrome, which can significantly improve the symptoms and signs of patients, promote the recovery of cellular immune function, hereby worthy of clinical promotion.