199例乙型肝炎病毒感染相关中晚期肝癌患者生存时间及影响因素的分析

Analysis of survival time and influencing factors of 199 cases of advanced liver cancer associated with hepatitis B virus infection

目的:分析并探讨乙型肝炎病毒(HBV)感染相关中晚期原发性肝癌(PLC)生存时间及影响因素。方法:选取1997年1月1日至2017年12月31日,在深圳市第三人民医院确诊为HBV感染相关中晚期原发性肝癌在院死亡患者199例,回顾性分析患者生存时间及其主要影响因素。结果:199例死亡患者首次确诊中晚期原发性肝癌后平均生存时间(4.985±1.262)月,中位生存时间2.00月。规律复诊、AFP、胆道系统结石、抗病毒治疗、手术及其他治疗、是否参与医保是患者生存时间的影响因素(P<0.05)。其中规律复诊、抗病毒治疗、手术及其他治疗、AFP是影响患者生存时间的独立因素,前面三个因素为影响生存时间的保护因素,而AFP反之。结论:本组HBV感染相关中晚期原发性肝癌死亡患者生存时间较短,规律复诊、抗病毒治疗、手术等干预对延长生存期有一定帮助。

Objective:To analysis and investigate the influence of factors on survival time of advanced liver cancer associated with hepati-tis B virus infection. Methods:Total of 199 patients,comfirmed died,diagnosed as HBV related advanced liver cancer between Jan 1st 1997 and Dec 31st 2017 in Shenzhen Third Hospital were analyzed, retrospectivly. The Kaplan-Meier survival analysis and Multivariate Cox analy- sis were performed to analysis. Results:In the 199 patients with death,the average survival time after the diagnosis of advanced liver cancer was 4. 985 ± 1. 262 months,and the median survival time was 2. 00 months. Regular follow-up,AFP,biliary stones,anti-viral therapy,surgery and /or other treatments,whether to participate in medical insurance were factors influencing patients’ survival time(P < 0. 05). Regular fol- low-up,anti-viral therapy,surgery and /or other treatments were the independent protective factors affecting the survival time of the patients. AndAFP,theopposite. Conclusion:The survival time of patients with advanced liver cancer associated with HBV infection in this group is shorter,regular follow-up,anti-viral treatment,surgery and /or other teratments will help to prolong survival partly.