摘要
2018年,对于慢性嗜肝病毒(HBV、HCV)感染的固有免疫应答与适应性免疫应答作用机制的研究,阐明了患者体内自然杀伤(NK)细胞、单核细胞、B细胞和T细胞功能异常;探索了免疫调控HBV感染的新靶点(TLR3/OX40L)。新的NK细胞免疫检查点的发现、单核巨噬细胞参与肝衰竭和肝脏炎症发生机制、性激素通过调节体液免疫影响肝内抗细菌感染、肝脏与其他免疫器官之间的交流机制均丰富了人们对于肝脏免疫学及其临床意义的认识。
The mechanism of innate and adaptive immune responses to chronic infections with hepatotropic viruses (HBV,HCV) was studied in 2018.Its mechanism elucidated the dysregulation of natural killer (NK) cells,monocytes,B cells and T cells.In addition,a new target for immune regulation of HBV infection (TLR3/OX40L) was introduced.The discovery of new NK cell immune checkpoints,the involvement of mononuclear macrophages in liver failure and inflammation,sex hormone affecting intrahepatic-resistant bacterial infection through the regulation of humoral immunity,and the communication mechanism between liver and other immune organs have enriched people's understanding of liver immunology and its clinical significance.
作者
吴珺
杜艳芹
杨东亮
Wu Jun;Du Yanqin;Yang Dongliang(Department of Infectious Diseases,Institute of Infection and Immunology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2019年第4期241-243,共3页
Chinese Journal of Hepatology
基金
国家自然科学基金(91642118、81672022)
“十三五”国家传染病科技重大专项(2017ZX10202202-001-009、2017ZX10202202-002-008)
天晴肝病研究基金(TQGE20190085).
