长链非编码RNAs在肾移植术后急性排斥反应中的研究进展

Role of lncRNAs in accurate rejection after kidney transplantation

肾移植术是目前终末期肾病最佳的治疗手段,根据肾移植术后排斥反应发生时间,排斥反应可分为超急性排斥反应、加速性排斥反应、急性排斥反应(AR)和慢性排斥反应。长链非编码RNA(lncRNAs)在机体多种病理生理过程中发挥重要作用,可影响组织的稳定性,与急性肾损伤、肾小球疾病及急性同种异体移植排斥反应等多种病理过程关系密切,并在肾移植术后AR早期诊断等方面潜力巨大,现将lncRNAs在肾移植急性排斥反应中的功能进行综述。

Kidney transplantation is the best treatment for end-stage renal disease. The types of the rejection can be divided into hyperacute rejection, accelerated rejection, acute rejection (AR) and chronic rejection according to the time of rejection after renal transplantation. Long noncoding RNAs (lncRNAs) play an important role in a variety of pathophysiological processes in the body, which can affect the stability of tissues. It is also closely related to various pathological processes such as acute kidney injury, glomerular disease and acute allograft rejection. What′s more, the scholars found its huge potential for early diagnosis of AR after renal transplantation. This article will summarize the function of lncRNA in acute rejection of renal transplantation.