针对食管胃结合部腺癌定义争论的探讨

Explore the definition of adenocarcinoma of esophagogastric junction

食管胃结合部腺癌所处解剖位置特殊,具有不同于食管癌及胃癌的生物学特性,故其在定义、临床分型及肿瘤分期等方面存在争议。目前公认的分型方法为Siewert分型,同时依据肿瘤所处部位建立了相对独立的TNM分期,能够更加准确地指导后续治疗及判断预后,因而本文旨在对食管胃结合部腺癌定义、食管胃结合部区域界定、临床分型及分期等方面进行系统阐述,期望未来能够通过进一步深入的基础、临床研究获得更多高级别的证据支持,为食管胃结合部腺癌精准治疗的开展提供重要依据。

Adenocarcinoma of esophagogastric junction is located in the special anatomical location, which is different from esophageal cancer and gastric cancer in biological characteristics. Therefore, the definition, clinical classification and tumor staging are controversial. Currently the classification of Siewert is accepted by worldwide. Meanwhile, there is a relatively independent TNM staging based on the tumor site, this TNM stage can guide subsequent treatment accurately and judge prognosis. Thus, clinicians need to further study about the definition of adenocarcinama of esophagogastric junction and esophagogastric junction, clinical classification and tumor stage. In addition, we expect to perform basic and clinical research in future to get more high level evidence in order to provide treatment accurately for patients.