帕金森病肠道起源学说的研究进展

Update on the theory of intestinal origin of Parkinson′s disease

帕金森病是一种以α-突触核蛋白异常聚集为特征的中枢神经系统退行性变。近年有研究发现,帕金森病可能起源于肠道。在帕金森病前驱期患者肠道中发现了异常聚集的α-突触核蛋白,动物模型提示异常聚集的α-突触核蛋白可通过迷走神经传播到中枢神经系统。帕金森病患者肠道渗透性增加、肠道氧化应激水平升高与α-突触核蛋白在肠道聚集并向中枢传播有关。

Parkinson′s disease (PD) is a progressive degenerative disease of the central nervous system, which is characterized by the aggregation of alpha-synuclein. Accumulating evidence suggests that PD may arise in the gut. Aggregation of alpha-synuclein was found in the enteric nervous system of patients with prodromal stage of PD, alpha-synuclein might spread from the enteric nervous system to the central nervous system through vagus nerve based on animal model. The increased permeability and oxidative stress of gut may also be associated with the aggregation of alpha-synuclein and its propagation from gut to the central nerve system.