复方槐花补骨脂酊联合二氧化碳点阵激光治疗稳定期肢端型白癜风的疗效观察

Efficacy of indine of composite Huaihua fructus posraleae combined with fractional CO2 laser on acral stable vitiligo

目的观察复方槐花补骨脂酊联合二氧化碳(CO2)点阵激光治疗稳定期肢端型白癜风的疗效及安全性。方法收集2014年10月至2017年8月东莞市第六人民医院收治的稳定期肢端型白癜风患者79例,根据治疗方法不同分为治疗组51例及对照组28例。治疗组患者予CO2点阵激光治疗,每月1次,连续治疗4次,激光治疗24 h后开始外搽复方槐花补骨脂酊,每天2次;对照组患者予复方槐花补骨脂酊外搽,每天2次。治疗3个月及6个月判定疗效。结果治疗3个月及6个月后,治疗组显效率分别为39.22%、62.75%,对照组显效率分别为32.14%、42.86%,治疗组与对照组显效率差异均有统计学意义(χ^2=12.557、18.021,均P<0.05);两组均未见明显不良反应。结论复方槐花补骨脂酊联合CO2点阵激光治疗稳定期肢端型白癜风疗效显著,安全性好。

Objective To evaluate the efficacy and safety of indine of composite Huaihua fructus posraleae combined with fractional CO2 laser on acral stable vitiligo. Methods From October 2014 to August 2017, 79 cases with acral stable vitiligo in the Sixth People′s Hospital of Dongguan were randomly divided into treatment group and control group according to the digital table. The treatment group(51 cases) was treated with fractional CO2 laser one time a month for four times, and the second day was given topical indine of composite Huaihua fructus posraleae twice a day. The control group(28 cases) was treated with topical indine of composite Huaihua fructus posraleae twice a day. The treatment effect was observed after treatment for 3 months and 6 months. Results After treatment for 3 months and 6 months, the total effective rates of the treatment group were 39.22%, 62.75%, respectively, which were significantly higher than those of the control group(32.14%, 42.86%)(χ^2=12.557, 18.021, all P<0.05). No serious adverse event was observed in the two groups. Conclusion Indine of composite Huaihua fructus posraleae combined with fractional CO2 laser is safe and effective in the treatment of stable sporadic vitiligo.