同血管重建手术治疗成人烟雾病的疗效分析

Clinical efficacy of different vascular reconstruction on adult moyamoya disease

目的探讨颞浅动脉-大脑中动脉搭桥联合脑-硬膜-动脉-颞肌贴敷术(STA-MCA+EDAMS)以及脑-硬膜-动脉-颞肌贴敷术(EDAMS)治疗成人烟雾病的安全性和有效性。方法回顾性分析2014年1月至2018年1月在浙江省台州医院神经外科接受血管重建术治疗的47例成人烟雾病患者的临床资料,其中接受单纯EDAMS者21例(EDAMS组),其中出血型烟雾病14例,缺血型烟雾病7例;接受STA-MCA联合EDAMS者26例(STA-MCA+EDAMS组),其中出血型烟雾病17例,缺血型烟雾病9例。比较2组术前1 d及术后3、6个月的脑血流动力学指标,按出血型和缺血型分别比较2种术式术后3、6个月的临床疗效及术后并发症情况。结果出血型烟雾病中STA-MCA+EDAMS组术后6个月的缓解率为94.1%(16/17),EDAMS组为57.1%(8/14),差异有统计学意义(P<0.05)。STA-MCA+EDAMS组术后3、6个月的脑血流量、脑血容量高于EDAMS组,平均通过时间、达峰时间低于EDAMS组,但差异均无统计学意义(均P>0.05)。不管是出血型烟雾病还是缺血型烟雾病,两种术式术后总并发症发生率差异均无统计学意义(均P>0.05)。结论颞浅动脉-大脑中动脉搭桥联合脑-硬膜-动脉-颞肌贴敷术以及脑-硬膜-动脉-颞肌贴敷术治疗成人烟雾病均可显著改善患者神经功能和脑血流动力学指标,安全性较高。

Objective To investigate the clinical efficacy of superficial temporal artery -middle cerebral artery combined with encephalo-duro-arterio-myo-synangiosis (STA-MCA+EDAMS) and encephalo-duro-arterio-myo-synangiosis (EDAMS) in the treatment of adult moyamoya disease. Methods The clinical data of 47 adult patients with moyamoya disease who received vascular reconstruction in the Department of Neurosurgery of Taizhou Hospital of Zhejiang Province from January 2014 to January 2018 were retrospectively analyzed. Among them, 21 patients received EDAMS alone (EDAMS group, 14 patients with hemorrhagic moyamoya disease, 7 patients with ischemic moyamoya disease), 26 patients received STA-MCA combined with EDAMS (STA-MCA+EDAMS group, 17 patients with hemorrhagic moyamoya disease, 9 patients with ischemic moyamoya disease). Cerebral hemodynamics at 1 day before surgery and 3 and 6 months after surgery were compared. The clinical efficacy and postoperative complications of the two methods were compared at 3 and 6 months postoperatively in hemorrhagic and ischemic types. Results For hemorrhagic moyamoya disease, the remission rate (94.1%) at 6 months after surgery in the STA-MCA + EDAMS group was higher than that in the EDAMS group (57.1%), and the difference was statistically significant (P<0.05). The CBF and CBV in the STA-MCA+EDAMS group were higher than those in the EDAMS group at 3 and 6 months after operation, and the MTT and TPP were lower than those in the EDAMS group, but there was no significant difference between the two groups (all P>0.05). For hemorrhagic moyamoya disease and ischemic moyamoya disease, the total incidence of postoperative complications of the two surgical methods was different, but the difference was not statistically significant (both P>0.05). ConclusionSuperficial temporal artery -middle cerebral artery combined with encephalo-duro- arterio-myo-synangiosis (STA-MCA+EDAMS) and encephalo-duro-arterio-myo-synangiosis (EDAMS) can significantly improve neurological function and cerebral hemodynamics in adult moyamoya disease patients with high safety.