肠道菌群在肝病领域的研究现状及应用展望

Current status and prospects on the clinical application of gut microbiota in liver diseases

肠道菌群与疾病存在着千丝万缕的联系。随着宏基因组学和生物信息学的发展,人们对其在疾病进程及诊断和治疗中的作用有了新的认知。本文着眼于肠道菌群与肝病的密切关联,分析和阐述了其研究现状及在临床诊疗中的应用价值和发展方向,指出通过菌群与机体的互作研究,发现新的致病通路、寻找相关药物靶点以及开发更灵敏的早期诊断标志物,无疑都会助力肝病的临床诊疗。

There′s a very complicated association between gut microbiota and diseases.With the development of metagenomics and bioinformatics,people have a new recognition of its role in pathogenesis,diagnosis and treatments.This review focuses on the close relationship between gut microbiota and liver diseases,analyzes and discusses the current research status,value of clinical applications and development directions.It is suggested that investigating the interactions between gut microbiota and body to discover new pathogenic pathway,maybe helpful in seeking for relevant drug targets and developing more sensitive early detection markers,then undoubtedly facilitate the clinical diagnosis and treatment of liver diseases.