循环肿瘤DNA在中晚期肿瘤精准医疗中的应用进展

Progress of circulating-tumor DNA in the precise medicine for advanced-stage cancer

循环肿瘤DNA(ctDNA)检测,作为液体活检技术之一,因其标本采集的非侵入性和反映肿瘤实时状态的特性,在肿瘤的精准诊断和治疗中具有巨大临床应用前景。目前,ctDNA分析方法通过临床验证,在肿瘤诊断和治疗中较为成功的应用领域主要集中在中晚期肿瘤的靶向药物选择、疗效评估及复发监测。虽然对ctDNA分析的关注快速增长,但其在肿瘤精准诊断中的广泛应用,还面临诸多挑战,尤其是对早期肿瘤的筛查和诊断。本文针对以上几个方面,就ctDNA在中晚期肿瘤精准医疗中的最新研究进展进行分析,以期给未来ctDNA相关研究提供参考。

Circulating tumor DNA (ctDNA) detection is one of "liquid biopsy" analysis.It has shown promising clinical application in cancer precise medicine due to its noninvasive sampling and real-time observation.Nowadays,ctDNA analysis has been clinically validated and successfully applied in advanced cancer,including selecting personalized treatment,monitoring treatment responses,minimal residual disease and recurrence.Although there has been rapidly increasing interests in ctDNA,its clinical application in cancer precise medicine is still facing few challenges,especially in screening and diagnosing cancer at early stages.Here,the latest progress in the applications and challenges of ctDNA in advancedstage tumor therapy were reviewed to provide references for future studies on ctDNA.