金凤丸联合芬吗通可改善薄性子宫内膜不孕患者妊娠结局

Jinfeng Pills combined with femoston can improve pregnancy outcomes in the infertile patients with thin endometrium

目的观察金凤丸联合芬吗通在薄性子宫内膜不孕患者中的临床应用。方法选取人绒毛膜促性腺激素(hCG)注射日子宫内膜<7mm经氯米芬促排卵后不孕的肾阳虚型薄性子宫内膜患者104例,按随机数字法随机分为对照组(口服氯米芬和芬吗通治疗,n=52),研究组(提前1个周期口服金凤丸行预处理,再予氯米芬和芬吗通联合金凤丸治疗,n=52),两组均治疗3个周期,比较两组治疗前、后以及治疗后妊娠组和非妊娠组在hCG注射日子宫内膜厚度、类型、血流及临床妊娠率。结果研究组和对照组的子宫内膜厚度在治疗后[(9.93±0.15)mm,(8.05±0.42)mm]明显大于治疗前[(5.97±0.16)mm,(5.99±0.14)mm,P<0.01],且研究组治疗后的子宫内膜厚度明显大于对照组(P<0.01)。研究组和对照组的子宫内膜类型、血流情况在治疗后比治疗前均有明显改善(P=0.01,P=0.04;P<0.01,P=0.04),治疗后研究组的子宫内膜血流改善情况与对照组差异有统计学意义(P=0.03)。治疗后妊娠组的子宫内膜厚度[(9.45±0.78)mm]、类型、血流等方面均较非妊娠组[(8.59±1.00)mm]有明显改善(P<0.01,P=0.04,P=0.04)。治疗后研究组的妊娠成功率(57.69%)优于对照组(40.62%)(P=0.02)。结论金凤丸联合芬吗通对氯米芬促排卵过程中因子宫内膜薄而不孕的肾阳虚型患者,可以有效地改善其子宫内膜厚度、类型、血流,提高临床妊娠率。

Objective To observe the application of Jinfeng Pills combined with femoston in the infertile patients with thin endometrium.Methods Total of 104 cases of infertility with thin endometrium after ovulation induction and insufficiency of the kidney-yang on the day of human chorionic gonadotropin(hCG)injection were randomly divided into control group(52 cases with oral clomiphene and femoston),and study group(52 cases,who were pretreated with oral Jinfeng Pills for one cycle,and then given clomiphene,femoston combined with Jinfeng Pills).The two groups were treated for three cycles.The endometrial thickness and type,blood flow,clinical pregnancy rate were compared between the two groups before and after the treatment,as well as between the pregnancy group and the non-pregnancy group on the day of ovulation.Results After treatment,endometrial thickness in both groups were significantly improved[(9.93±0.15)mm,(8.05±0.42)mm vs.(5.97±0.16)mm,(5.99±0.14)mm,P<0.01],and study group was superior to control group(P<0.01).Endometrium type and blood flow after treatment were significantly improved compared with those before treatment(P=0.01,P=0.04,P<0.01,P=0.04),and the endometrium blood flow in study group was superior to control group(P=0.03).After treatment,the endometrial thickness[(9.45±0.78)mm vs.(8.59±1.00)mm],type and blood flow in pregnancy group were significantly improved compared with non-pregnancy group(P<0.01,P=0.04,P=0.04).Study group was superior to control group in clinical pregnancy rate(57.69%vs.40.62%,P=0.02).Conclusion The combination of Jinfeng Pills and femoston can effectively improve the endometrial thickness,type and blood flow of endometrium,and improve the clinical pregnancy rate in clomiphene-induced ovulation patients with thin endometrium and infertility due to indufficiency of the kidney-yang.