内源性大麻素系统对子宫内膜容受性的作用

Effect of endocannabinoids system on endometrial receptivity

子宫内膜容受性主要是指孕激素介导的子宫内膜间质细胞向蜕膜细胞增殖、分化的过程,对于胚胎植入的早期阶段是至关重要的。内源性大麻素系统(ECS)参与人体各种生理活动,广泛分布于中枢神经系统,对于代谢和生殖起着十分重要的调节作用。其中主要的内源性大麻素物质——N-花生四烯酰基乙醇胺(AEA)动态变化参与妊娠早期过程,特别是胚胎种植期。本文就子宫内膜容受性与ECS间的关系进行综述,探讨ECS对子宫内膜容受性的作用,进一步阐述其对妊娠的影响。

Endometrial receptivity refers to a progesterone-mediated period in which the endometrial tissue undergoes cell proliferation and differentiation.It’s crucial for the early stage of embryo implantation.Endocannabinoids system(ECS)participates in body’s physiological metabolism,which has a wide distributing in central nervous system and plays an important role in regulating metabolism and reproduction.The dynamic changes of the main endocannabinoid-N-arachidonoylethanolamine(AEA)are involved in the early embryonic development.In this review,we briefly give an overview of the relationship between endometrial receptivity and ECS,to explore the effect of ECS in endometrial receptivity and pregnancy.