基于嗜酸粒细胞性炎症的慢性鼻窦炎伴鼻息肉的分类方法

Classification of chronic rhinosinusitis with nasal polyps based on eosinophilic inflammation

慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)是一种异质性的鼻腔及鼻窦黏膜的慢性炎性疾病,根据其局部鼻黏膜组织嗜酸粒细胞浸润程度不同可分为嗜酸粒细胞性CRSwNP及非嗜酸粒细胞性CRSwNP。二者在临床表现、预后及细胞和免疫病理学机制上均存在明显差异。然而,目前并没有统一的标准来界定嗜酸粒细胞性CRSwNP。本文归纳并比较了目前常用的基于嗜酸粒细胞性炎症的CRSwNP的分类方法及其优缺点,以期为此类研究提供基础。

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disorder characterized by chronic sinonasal mucosal inflammation. CRSwNP can be subdivided into two types based on eosinophilic inflammation: eosinophilic CRSwNP (Eos CRSwNP) and non-eosinophilic CRSwNP (Non-Eos CRSwNP). Eos CRSwNP and Non-Eos CRSwNP demonstrate distinct clinical manifestations, treatment outcomes, and cellular and immunopathologic characteristics. However, currently, there is no unified and generally accepted standard to define the Eos CRSwNP. The aim of this review is to compare the advantages and disadvantages of current methods used to classify Eos CRSwNP, in order to lay foundation for further study.