为有兴奋激越症状的急性期精神分裂症患者使用喹硫平与氟哌啶醇进行治疗的效果对比

To compare the efficacy of quetiapine and haloperidol in the treatment of acute stage schizophrenia with excitatory symptoms

目的 :比较为有兴奋激越症状的急性期精神分裂症患者使用喹硫平与氟哌啶醇进行治疗的效果。方法 :选取都江堰市第三人民医院收治的48例具有兴奋激越症状的急性期精神分裂症患者作为研究对象。将这48例患者平均分为A组和B组。为A组患者使用氟哌啶醇进行治疗。为B组患者使用喹硫平进行治疗。然后,比较两组患者药物的起效率及不良反应的发生率。结果 :在接受治疗后的第1 d、第3 d、第7 d及第14 d,两组患者药物的起效率相比,差异不具有统计学意义(P>0.05)。接受治疗后,B组患者不良反应的发生率低于A组患者(P <0.05)。结论 :为有兴奋激越症状的急性期精神分裂症患者使用喹硫平或氟哌啶醇进行治疗的效果均很好。但与使用氟哌啶醇相比,为此类患者使用喹硫平进行治疗后,其不良反应的发生率更低。

Objective:To compare the efficacy of quetiapine and haloperidol in the treatment of acute stage schizophrenia with excitation-agitation symptoms.Methods:a total of 48 patients with acute stage schizophrenia who were admitted to the third people’s hospital of dujiangyan city were selected as subjects.The 48 patients were divided into group A and group B on average.Group A patients were treated with haloperidol.Patients in group B were treated with quetiapine.Then,the efficacy and incidence of adverse reactions were compared between the two groups.Results:at day 1,day 3,day 7 and day 14 after treatment,there was no statistically significant difference in the starting efficiency between the two groups(P>0.05).After treatment,the incidence of adverse reactions in group B was lower than that in group A(P<0.05).Conclusion:both quetiapine and haloperidol are effective in the treatment of acute stage schizophrenia with agitation.However,the incidence of adverse reactions in patients treated with quetiapine was lower than that treated with haloperidol.