Ⅱ型固有淋巴细胞在慢性阻塞性肺疾病中的研究进展

Research progress on type Ⅱ innate lymphoid cells in chronic obstructive pulmonary disease

Ⅱ型固有淋巴细胞(ILC2s)是固有淋巴细胞家族中新发现的成员之一。ILC2s在转录因子维甲酸相关孤核受体α和GATA结合因3调控下由骨样淋巴祖细胞发育而来,主要分布于皮肤、肺脏、肠道等黏膜组织。ILC2s可被IL-25、IL-33和胸腺基质淋巴细胞生成素刺激产生IL-5和IL-13等Th2型细胞因子,在抗寄生虫感染、病毒感染、组织修复和呼吸道炎症中发挥重要的功能。本文综述ILC2s的生物学特征和功能,并特别关注了ILC2s在慢性阻塞性肺疾病中的作用。

Type Ⅱ innate lymphoid cells (ILC2s) are one of the newly discovered members of the innate lymphocyte family.ILC2 cell is thought to differentiate from the Common Lymphoid Progenitor and rely on the transcription factor RORα and GATA-binding factor3 for development, mainly distributed in tissues such as skin, lungs, and intestines.ILC2s are capable of producing Th2-type cytokines including IL-5 and IL-13 in response to IL-25 and IL-33. Meanwhile, ILC2s was able to fulfill vital functions in parasite clearance, anti-virus infection, subsequent tissue repair and airway inflammation.This article reviews the biological characteristics and functions of ILC2s, with particular attention to the role of ILC2s in chronic obstructive pulmonary disease.