肿瘤相关巨噬细胞分泌的细胞因子在肿瘤微环境中作用的研究进展

Advances in the role of cytokines secreted by tumor-associated macrophages in tumor microenvironment

肿瘤微环境(TME)内含多种细胞以及多种细胞因子,在肿瘤的增殖、侵袭以及转移上都起到了重要的作用。肿瘤相关巨噬细胞(TAMs)作为TME的重要组成部分,主要通过其分泌的细胞因子与肿瘤细胞相互作用,进而调控肿瘤的进展。本文对TAMs分泌的细胞因子在TME中的作用进行概述,包括肿瘤的侵袭、迁移以及血管生成等。靶向TME中TAMs分泌细胞因子进行干预,有望成为肿瘤一种新的治疗策略。

Tumor microenvironment (TME) contains multiple cells and cytokines, which play an important role in tumor proliferation, invasion and metastasis. Tumor-associated macrophages (TAMs), as an important component of TME, mainly interact with tumor cells through the cytokines secreted by them to further regulate tumor progression. In this paper, the role of cytokines secreted by TAMs in TME was summarized, including tumor invasion, migration and angiogenesis. Targeting TAMs secreted cytokines in TME for intervention is expected to be a new therapeutic strategy for tumors.