丙戊酸镁治疗双相情感障碍对患者血清总胆红素、白蛋白、炎性因子水平和生活质量的影响

Effect of magnesium valproate on serum total bilirubin, albumin, inflammatory factors and quality of life in patients with bipolar affective disorder

目的分析丙戊酸镁治疗双相情感障碍对患者血清总胆红素(TBIL)、白蛋白、炎性因子水平和生活质量的影响。方法选取广西壮族自治区脑科医院2017年8月～2018年7月收治的双相情感障碍100例患者的临床资料进行回顾性分析,按照治疗方法不同分为对照组和观察组,每组各50例。对照组患者采用碳酸锂治疗,观察组患者采用丙戊酸镁治疗,分析两组患者的治疗效果。结果观察组患者总有效率高于对照组,差异有统计学意义(P <0.05)。两组患者治疗后肿瘤坏死因子-α(TNF-α)、尿酸(UA)水平较治疗前下降,TBIL、血清白蛋白较治疗前上升,且观察组患者治疗后TNF-α、UA水平低于对照组,TBIL、血清白蛋白水平高于对照组,差异均有统计学意义(均P <0.05)。两组患者治疗后汉密尔顿抑郁量表(HAMD)评分、狂躁量表(BRMS)评分较治疗前下降,健康调查简表(SF-36)评分较治疗前上升,且观察组患者HAMD评分、BRMS评分低于对照组,SF-36评分高于对照组,差异均有统计学意义(均P <0.05)。观察组患者不良反应发生率低于对照组,差异有统计学意义(P <0.05)。结论丙戊酸镁治疗双相情感障碍患者效果明显,改善患者生活质量,减轻狂躁及抑郁情况,降低不良反应发生率,值得临床推广应用。

Objective To analyze the effect of magnesium valproate on serum total bilirubin (TBIL), albumin, inflammatory factor level and quality of life in patients with bipolar affective disorder. Methods The clinical data of 100 patients with bipolar affective disorder admitted in Guangxi Zhuang Autonomous Region Brain Hospital from August 2017 to July 2018 were retrospectively analyzed and divided into control group and observation group according to different treatment methods, each group had 50 cases. The patients in the control group were treated with lithium carbonate, and the patients in the observation group were treated with magnesium valproate, to analyze the effect of the two groups after treatment. Results The total effective rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (P < 0.05). After treatment, the levels of tumor necrosis factor-α(TNF-α) and uric acid (UA) decreased, TBIL, serum albumin increased after treatment, and the levels of TNF-α and UA in the observation group were lower than those in the control group, and the serum albumin level of TBIL was higher than that of the control group, and the differences were statistically significant (all P < 0.05). After treatment, the scores of hamilton depression scale (HAMD), mania scale (BRMS) and health survey summary form (SF-36) were decreased, and the HAMD and BRMS scores of the patients in the observation group were lower than those of the control group, and the SF-36 score was higher than that of the control group, and the differences were statistically significant (all P < 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, the difference was statistically significant (P < 0.05). Conclusion The effect of magnesium valproate on bipolar affective disorder patients is obvious. It can improve the quality of life, reduce the condition of mania and depression, and reduce the incidence of adverse reactions. It is worth popularizing and applying in clinic.