降钙素原、超敏C反应蛋白、红细胞沉降率及S100A9对肺结核合并肺部细菌感染的影响

Effects of procalcitonin, Hypersensitive C-reactive protein, erythrocyte sedimentation rate and S100A9 on pulmonary tuberculosis complicated with bacterial infection

目的比较降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、红细胞沉降率(ESR)及S100A9蛋白对肺结核合并肺部细菌感染中的影响。方法选取2017年9月～2018年8月首都医科大学附属北京胸科医院收治的确诊为肺结核的132例,并根据是否合并肺部细菌感染分为细菌感染组(62例)及单纯肺结核组(70例),对其外周血血浆标本应用免疫荧光法检测PCT,ELISA方法测定S100A9水平,免疫比浊法测定hs-CRP,魏氏法测定ESR。结果细菌感染组患者的PCT、S100A9蛋白及hs-CRP水平与单纯肺结核组比较均显著性增高(P <0.01)。多因素分析PCT及S100A9为肺结核合并肺部细菌感染的独立危险因素。结论肺结核患者PCT及S100A9水平对监测患者是否合并肺部细菌感染具有良好的临床应用价值。

Objective To compare the effects of procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR) and S100A9 protein on pulmonary tuberculosis complicated by bacterial infection. Methods Form September 2017 to August 2018 in Beijing Chest Hospital Affiliated to Capital University of Medical Sciences, 132 cases were diagnosed as tuberculosis, and according to whether the pulmonary bacterial infection they were divided into bacterial infection group (62 cases) and simple tuberculosis group (70 cases), the peripheral blood plasma samples application immunofluorescence test PCT, ELISA method for determination of S100A9 level, immunoturbidimetry was used to determine hs-CRP, the ESR was determined by the Weiss method. Results The levels of PCT, S100A9 and hs-CRP in the bacterial infection group were significantly higher than those in the pure tuberculosis group (P < 0.01). Multivariate analysis showed that PCT and S100A9 were independent risk factors for pulmonary tuberculosis complicated by bacterial infection. Conclusion The levels of PCT and S100A9 in pulmonary tuberculosis patients have good clinical application value in monitoring whether the patients are complicated with pulmonary bacterial infection.