氟米龙配合更昔洛韦治疗HSK疗效与安全性观察

Curative effect and safety of fluorometholone combined with ganciclovir in the treatment of HSK

目的探析氟米龙配合更昔洛韦治疗单纯疱疹病毒性角膜炎(HSK)疗效与安全性。方法选取2015年6月至2018年1月本院收治的HSK患者110例,采用随机抽签法分为观察组与对照组,各55例,对照组采用更昔洛韦眼凝胶治疗,观察组在对照组基础上加用氟米龙滴眼液联合治疗,观察两组患者治疗有效率、症状缓解时间、不良反应发生率及复发率。结果两组患者治疗有效率分别为94.55%、80.00%,观察组明显高于对照组(P<0.05);两组患者治疗后视力较治疗前均明显升高(P<0.05),观察组治疗后视力明显高于对照组(P<0.05),眼部疼痛缓解时间及角膜愈合时间均显著短于对照组(P<0.05);两组患者不良反应发生率分别为5.45%、9.09%,差异无统计学意义,复发率分别为9.09%、25.45%,观察组明显低于对照组(P<0.05)。结论 HSK患者采用氟米龙配合更昔洛韦治疗可显著提高治疗效果,明显缓解临床症状,促进角膜修复愈合,复发率低,安全性高。

Objective To investigate the curative effect and safety of fluorometholone combined with ganciclovir in the treatment of herpes simplex keratitis(HSK). Methods 110 patients with HSK admitted to the hospital from June 2015 to January 2018 were randomly divided into the observation group and the control group with 55 cases in each group. The control group was treated with ganciclovir eye gel while the observation group was treated with fluorometholone eye drops, based on the treatment for the control group. The treatment response rates, time to symptom relief, incidence of adverse reactions and recurrence rates in both groups were observed. Results The treatment response rate of the observation group was significantly higher than that of the control group(94.55% vs 80.00%)(P<0.05). The visual acuity of both groups was significantly improved after treatment(P<0.05), and the visual acuity of the observation group was significantly higher than that of the control group after treatment(P<0.05). The time to eye pain relief and corneal healing time of the observation group was significantly shorter than that of the control group(P<0.05).The incidence of adverse reactions in the two groups was 5.45% and 9.09%, respectively, and the difference was not statistically significant. The recurrence rate was 9.09% and 25.45%, respectively. The observation group was significantly lower than the control group(P<0.05). Conclusion The treatment with fluorometholone combined with ganciclovir for HSK can significantly improve the curative effect, relieve clinical symptoms, and promote corneal healing, with low recurrence rate and high safety.