ADAMTS?1表达水平与急性心肌梗死面积和心血管结局的关系

Relationship between expression level of ADAMTS-1 and the area and cardiovascular outcome of acute myocardial infarction

目的分析Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶(ADAMTS-1)表达水平与急性心肌梗死面积和心血管结局之间的关系。方法 2016年1月至2017年9月期间,筛选115例符合条件的急性心肌梗死(AMI)患者进行研究,并纳入健康志愿者50例作为对照组,分析组间血浆ADAMTS-1水平变化,比较有无发生心血管事件的组间在入院时ADAMTS-1水平差异,以及入院时不同ADAMTS-1水平患者发生心血管事件的差异。结果和对照组相比,AMI组血浆ADAMTS-1水平均明显升高(P <0.05),且前壁心肌梗死组较下壁心肌梗死组高(P <0.05)。两组AMI患者在心梗面积上的差异有统计学意义(P <0.05),表现为前壁心肌梗死组较下壁心肌梗死组大。在发生心血管事件的患者中,其入院时血浆ADAMTS-1水平均高于未发生心血管事件的患者,其中死亡患者、心力衰竭患者以及再发心绞痛患者血浆ADAMTS-1水平在发生组和未发生组之间具有明显差异(P <0.05)。入院时血浆ADAMTS-1水平<116μg/L组的患者发生心血管事件的比例远远低于≥116μg/L组(P <0.05)。结论 AMI患者血浆ADAMTS-1升高,且前壁心肌梗死高于下壁心肌梗死,随着心肌梗死面积的增加,ADAMTS-1水平逐渐升高,ADAMTS-1水平越高,发生心血管事件比例越高。

Objective To analyze the relationship between expression level of type I platelet binding protein motif depolymerized protein like metalloproteinase(ADAMTS-1)and the area and cardiovascular outcome of acute myocardial infarction(AMI).Methods 115 patients with AMI in our hospital from January 2016 to September 2017 were selected,and 50 healthy volunteers were included in a control group.Plasma ADAMTS-1 level in groups were analyzed.Differences in ADAMTS-1 levels at admission between groups with cardiovascular events and groups without were compared.Differences in cardiovascular events of patients with different ADAMTS-1 levels at admission were compared.Results Compared with the control group,the level of plasma ADAMTS-1 in the AMI group was significantly increased(P<0.05).The level in the group of patients with anterior wall myocardial infarction was higher than the group of lower wall myocardial infarction(P<0.05).There were significant statistical differences(P<0.05)of myocardial infarction area between these two groups of AMI patients.The are in the anterior wall myocardial infarction group was larger than the inferior myocardial infarction group.The plasma ADAMTS-1 level at admission of patients with cardiovascular events was higher than those without.The plasma ADAMTS-1 levels were significantly different(P<0.05)between the occurrence group and the non occurrence group of patients experi enced death,heart failure,and angina pectoris.The incidence of cardiovascular events in the group of patients with plasma ADAMTS-1 level at<116μg/L was much lower than the group≥116μg/L(P<0.05).Conclusion In groups of patients with AMI,plasma ADAMTS-1 is higher;anterior wall myocardial infarction is higher than inferior wall myocardial infarction;the area of myocardial infarction increases with the increase of plasma ADAMTS-1 level;the higher ADAMTS-1 level,the higher proportion of patients suffer from cardiovascular events.