摘要
目的评价补肾调轴方改善体外受精-胚胎移植(IVF-ET)反复种植失败者子宫免疫微环境的临床疗效。方法将47例反复种植失败的患者作为研究对象,予补肾调轴方颗粒进行治疗,检测子宫内膜uNK细胞标记物CD56+、CD16+的表达。结果治疗后CD56+、CD16+的表达较治疗前下降,差异有统计学意义(P<0.05)。结论中药补肾调轴方能下调uNK细胞中CD56+、CD16+表达,促进胚胎免疫耐受,有助于胚胎的着床成功。
Objective:To evaluate the clinical effect of Bushen Tiaozhou Prescription for improving the uterine immune microenvironment in patients undergoing in vitro fertilization-embryo transfer (IVF-ET)repeated implantation. Methods:47 patients who failed in repeated implantation were treated with Bushen Tiaozhou Granule to detect the expression of endometrial uNK cell markers CD56+ and CD16+. Results:The expression of CD56+ and CD16+ decreased after treatment,and the difference was statistically significant. Conclusion:Bushen Tiaozhu Prescription can down-regulate the expression of CD56+ and CD16+ in uNK cells,promote embryonic immune tolerance,and contribute to the successful implantation of embryos.
出处
《云南中医中药杂志》
2019年第4期22-24,共3页
Yunnan Journal of Traditional Chinese Medicine and Materia Medica
基金
天津市中医药管理局中医
中西医结合科研专项课题(2015014)
天津市中医药研究院附属医院科研专项课题
