不同心脏病心肌细胞糖脂代谢与自噬关系的研究进展

Progress on Relationship between Glucolipid Metabolism and Autophagy in Myocardial Cells in Different Types of Heart Disease

心肌能量代谢指心肌细胞利用底物合成能量物质及储存、利用能量的全过程,而糖脂代谢是心肌能量代谢网络调控的主要内容,在不同病理生理条件下心肌细胞糖脂代谢发生改变以适应能量需求。自噬指细胞利用细胞内溶酶体清除过量或受损的长t1/2蛋白质及细胞器的现象,其启动和调控主要受细胞营养水平影响。近年研究发现,心肌细胞能量代谢紊乱在心脏病发生发展过程中具有重要作用。本文主要综述了不同心脏病心肌细胞糖脂代谢与自噬的关系,旨在从能量代谢角度为心脏病的治疗提供参考。

Myocardial energy metabolism means the whole process of compounding energy substance by using substrates,storing and using energy in myocardial cells,while glucolipid metabolism is the main component of myocardial energy metabolism network regulation,thus the glucolipid metabolism changed in myocardial cells in different pathophysiological conditions to adapt the energy requirement.Autophagy means removing over-dose or damaged proteins with long t1/2 and organelles by using cytolysosome in cells,and its startup and regulation were mainly affected by cell nutrient level.Recent researched found that,metabolism disorder of myocardial cell energy plays an important role in the occurrence and development of heart disease.This paper mainly reviewed the relationship between glucolipid metabolism and autophagy in myocardial cells in different types of heart disease,to provide a reference for the treatment of heart disease from the perspective of energy metabolism.